Moratalla R, Sánchez-Franco F, Del Río J
Life Sci. 1986 Jan 13;38(2):109-15. doi: 10.1016/0024-3205(86)90002-0.
Vasopressin antiserum was given to two day old rats and the nociceptive thresholds were evaluated three months later. The rats were hypersensitive to pain when electrical current, but not heat, was used as the noxious stimulus. These animals were also insensitive to cold-water swim, a non-opioid form of stress analgesia. The vasopressin content in the pituitary or in the hypothalamus was not however modified by the neonatal treatment. The present results suggest a physiological role for vasopressin in non-opioid pain inhibitory systems.
向两日龄大鼠注射抗加压素血清，并于三个月后评估其痛觉阈值。当使用电流而非热作为有害刺激时，这些大鼠对疼痛敏感。这些动物对冷水游泳也不敏感，冷水游泳是一种非阿片类应激镇痛形式。然而，新生儿期的治疗并未改变垂体或下丘脑的加压素含量。目前的结果表明，加压素在非阿片类疼痛抑制系统中具有生理作用。
