Tyler D C, Murphy J, Cheney F W
Pediatrics. 1978 Oct;62(4):454-9.
We investigated the effects of meconium on the lungs of an adult rabbit model to distinguish between mechanical obstruction of airways and chemical pneumonitis. After the rabbits were anesthetized and intubated, 20% human meconium in saline was instilled into the trachea. Arterial and mixed venous blood gases, functional residual capacity, cardiac output vascular pressures, calculated venous admixture, and pulmonary vascular resistance were measured. Sections of affected lung tissue were examined microscopically. The results were consistent with an early mechanical obstruction of airways with gradual development of chemical pneumonitis over 48 hours.
我们研究了胎粪对成年兔模型肺部的影响，以区分气道机械性阻塞和化学性肺炎。在兔麻醉并插管后，将20%的人胎粪生理盐水溶液注入气管。测量动脉血和混合静脉血气、功能残气量、心输出量、血管压力、计算静脉混合血和肺血管阻力。对受影响的肺组织切片进行显微镜检查。结果与气道早期机械性阻塞一致，并在48小时内逐渐发展为化学性肺炎。
