Barra J A, Deredec D, Tanguy L, Pavie A, Legendre P, de La Faye D, Raut Y, Cabrol C
Poumon Coeur. 1982;38(4):235-44.
Maintenance of myocardial cooling during aortic clamping is a problem encountered currently during heart surgery. A plastic foam isolation pad was studied. Eight animals (pigs weighing 50 kg) were placed on extracorporeal circulation, 4 of them constituting the control group (A). Two coronary injections of a cardioplegic solutions were administered, the first at the time of aortic clamping and the second 30 minutes later. The myocardium of the 4 animals in the treated group (B) was isolated with the foam pad, and this significantly prolonged the "cold" effect of the cardioplegic. Ten minutes after injection of the cardioplegic, temperature of the total myocardial mass with isolation was between 10.7 and 12 degrees C, as against 16 to 18 degrees C in the reference group (p less than 0.05). By the 20th minute, the isolated myocardium was at approximately 15 degrees C as against 22 degrees C in group A (p less than 0.01). Finally, by the 30th minute, temperature in group B was 17 degrees C as against 23 degrees C in group A (p less than 0.01). Reheating of the heart was significantly slowed by thermal isolation, though the limit of 15 degrees C was reached by the 20th minute. To ensure that myocardial temperature remains below this limit when the foam pad is employed, further injections of cardioplegic solutions are necessary every 20 minutes.
在心脏手术中,主动脉钳夹期间维持心肌低温是目前面临的一个问题。对一种塑料泡沫隔离垫进行了研究。将8只动物(体重50千克的猪)置于体外循环,其中4只构成对照组(A组)。进行了两次冠状动脉注射心脏停搏液,第一次在主动脉钳夹时,第二次在30分钟后。治疗组(B组)的4只动物的心肌用泡沫垫进行隔离,这显著延长了心脏停搏液的“低温”效果。注射心脏停搏液10分钟后,隔离情况下整个心肌块的温度在10.7至12摄氏度之间,而参照组为16至18摄氏度(p<0.05)。到第20分钟时,隔离的心肌约为15摄氏度,而A组为22摄氏度(p<0.01)。最后,到第30分钟时,B组温度为17摄氏度,而A组为23摄氏度(p<0.01)。热隔离显著减缓了心脏复温,不过到第20分钟时达到了15摄氏度的界限。为确保使用泡沫垫时心肌温度保持在该界限以下,每20分钟需要进一步注射心脏停搏液。