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喷雾干燥在制药中的应用(作者译)

[The use of spray drying in pharmacy (author's transl)].

作者信息

Kala H, Traue J, Moldenhauer H, Zessin G

出版信息

Pharmazie. 1979 Dec;34(12):779-84.

PMID:397493
Abstract

Owing to the favourable physical conditions of the evaporation process, the technique of spray drying has been used for some time to obtain dried products from solutions, suspensions, emulsions and fluid extracts. In the pharmaceutical industry, it may be utilized as a -drying technique, -micronizing procedure, -procedure for the manufacture of polymorphic or amorphic forms of active substances, -technique for producing microcapsules and spray embeddings, -method for manufacturing direct-tablettable active substances. The technical development which ranges from spray dryers for laboratory experiments to industrial plants, and the continuous operation are favourable prerequisites for research and use on an ever greater scale.

摘要

由于蒸发过程有利的物理条件,喷雾干燥技术已被使用了一段时间,用于从溶液、悬浮液、乳液和流体提取物中获得干燥产品。在制药行业,它可用作干燥技术、微粉化工艺、制造活性物质多晶型或无定形形式的工艺、生产微胶囊和喷雾包埋物的技术、制造直接压片活性物质的方法。从实验室实验用喷雾干燥器到工业装置的技术发展以及连续操作,是进行更大规模研究和应用的有利前提条件。

相似文献

1
[The use of spray drying in pharmacy (author's transl)].喷雾干燥在制药中的应用(作者译)
Pharmazie. 1979 Dec;34(12):779-84.
2
Process characteristics and compaction of spray-dried emulsions containing a drug dissolved in lipid.含有溶解于脂质中的药物的喷雾干燥乳剂的工艺特性与压实
Int J Pharm. 2004 Dec 9;287(1-2):55-66. doi: 10.1016/j.ijpharm.2004.08.014.
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Compressed biodegradable matrices of spray-dried PLGA microspheres for the modified release of ketoprofen.用于酮洛芬控释的喷雾干燥PLGA微球的压缩可生物降解基质。
J Microencapsul. 2003 Mar-Apr;20(2):193-201.
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Coprocessing via spray drying as a formulation platform to improve the compactability of various drugs.通过喷雾干燥进行共处理作为一种制剂平台以改善各种药物的可压性。
Eur J Pharm Biopharm. 2008 May;69(1):320-34. doi: 10.1016/j.ejpb.2007.11.009. Epub 2007 Nov 23.
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Process design applied to optimise a directly compressible powder produced via a continuous manufacturing process.应用工艺设计来优化通过连续制造工艺生产的直接压片粉末。
Eur J Pharm Biopharm. 2008 Mar;68(3):760-70. doi: 10.1016/j.ejpb.2007.09.007. Epub 2007 Sep 25.
6
[On the polymorphism of barbiturates in powders and tablets. 6: Properties and behaviour of a spray-dried barbital preparation].[关于巴比妥类药物在散剂和片剂中的多晶型现象。6:喷雾干燥巴比妥制剂的性质与行为]
Pharmazie. 1982 Aug;37(8):562-5.
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Physical characteristics and aerosol performance of naringin dry powders for pulmonary delivery prepared by spray-drying.喷雾干燥法制备的用于肺部给药的柚皮苷干粉的物理特性和气溶胶性能
Eur J Pharm Biopharm. 2009 May;72(1):206-13. doi: 10.1016/j.ejpb.2008.10.007. Epub 2008 Nov 1.
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[Relationships between manufacturing parameters and pharmaceutical-technological requirements of biodegradable microparticles. 2. Preparation of injectable microparticles in biodegradable polyester].[可生物降解微粒的制造参数与药物技术要求之间的关系。2. 可生物降解聚酯中注射用微粒的制备]
Pharmazie. 1992 Feb;47(2):115-9.
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beta-Glucuronidase activity following complex coacervation and spray drying microencapsulation.复凝聚和喷雾干燥微囊化后的β-葡萄糖醛酸酶活性
J Microencapsul. 1998 Sep-Oct;15(5):569-79. doi: 10.3109/02652049809008241.
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Evaluation of drug physical form during granulation, tabletting and storage.制粒、压片及储存过程中药物物理形态的评估。
Int J Pharm. 2004 May 4;275(1-2):29-39. doi: 10.1016/j.ijpharm.2004.01.042.

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