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喷雾干燥在制药中的应用(作者译)

[The use of spray drying in pharmacy (author's transl)].

作者信息

Kala H, Traue J, Moldenhauer H, Zessin G

出版信息

Pharmazie. 1979 Dec;34(12):779-84.

PMID:397493
Abstract

Owing to the favourable physical conditions of the evaporation process, the technique of spray drying has been used for some time to obtain dried products from solutions, suspensions, emulsions and fluid extracts. In the pharmaceutical industry, it may be utilized as a -drying technique, -micronizing procedure, -procedure for the manufacture of polymorphic or amorphic forms of active substances, -technique for producing microcapsules and spray embeddings, -method for manufacturing direct-tablettable active substances. The technical development which ranges from spray dryers for laboratory experiments to industrial plants, and the continuous operation are favourable prerequisites for research and use on an ever greater scale.

摘要

由于蒸发过程有利的物理条件,喷雾干燥技术已被使用了一段时间,用于从溶液、悬浮液、乳液和流体提取物中获得干燥产品。在制药行业,它可用作干燥技术、微粉化工艺、制造活性物质多晶型或无定形形式的工艺、生产微胶囊和喷雾包埋物的技术、制造直接压片活性物质的方法。从实验室实验用喷雾干燥器到工业装置的技术发展以及连续操作,是进行更大规模研究和应用的有利前提条件。

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