Fürst W, Neubert R, Stütz B, Fuchs G, Buchmann E
Pharmazie. 1982 Aug;37(8):571-7.
In connection with the function of a newly constructed absorption model the problem of interpretation of values obtained by models in regard of bioavailability is discussed. Wrong interpretations can be obtained if nonanalogous values are compared. An interpretation is proposed to calculate a value which is analogous to the relative bioavailability (calculated bioavailability). The efficiency of the absorption model and of the interpretation method is demonstrated by three examples of preparations of phenytoin, digoxin and chloramphenicol. We compared these results with the bioavailability of these preparations and we found a good correspondence.
结合一个新构建的吸收模型的功能，讨论了关于生物利用度的模型所得值的解释问题。如果比较不相似的值，可能会得到错误的解释。提出了一种解释方法来计算一个与相对生物利用度（计算生物利用度）相似的值。通过苯妥英、地高辛和氯霉素制剂的三个实例证明了吸收模型和解释方法的有效性。我们将这些结果与这些制剂的生物利用度进行了比较，发现两者吻合良好。
