Furlow T W
Stroke. 1982 Nov-Dec;13(6):852-5. doi: 10.1161/01.str.13.6.852.
Cerebral ischemia was produced in the rat by simultaneous occlusion of the vertebral and carotid arteries according to the method of Pulsinelli and Brierley (Stroke 10: 267, 1979). Local cerebral blood flow (CBF) was determined by polarographic and autoradiographic techniques. Hydrogen-clearance measurements showed that mean CBF fell in four monitored regions of the hemispheres to between 0.11 and 0.18 ml/g/min, being least in deep rostal gray, intermediate in superficial gray, and greatest in deep caudal gray. However, individual animals had local CBF in excess of 0.20 and even 0.30 ml/g/min, and no animal showed zero CBF. When animals were rendered hypotensive (MABP of 50 Torr) during vascular occlusion, mean CBF ranged between 0.03 and 0.10 ml/g/min in the same regional order. With hypotension, total arrest of flow occurred. Autoradiographic data confirmed the above findings and indicated adequate CBF to the lower brainstem. During vascular occlusion, sufficient CBF may be present ot sustain cerebral tissue as in animals with a well developed spinal circulation or an inadvertently patent vertebral artery.
根据普尔西内利和布赖尔利的方法（《中风》10: 267, 1979），通过同时阻断大鼠的椎动脉和颈动脉来制造脑缺血。采用极谱法和放射自显影技术测定局部脑血流量（CBF）。氢清除率测量显示，半球的四个监测区域的平均脑血流量降至0.11至0.18毫升/克/分钟之间，在脑前部深层灰质中最低，在浅层灰质中居中，在脑后部深层灰质中最高。然而，个别动物的局部脑血流量超过0.20甚至0.30毫升/克/分钟，没有动物的脑血流量为零。当动物在血管闭塞期间出现低血压（平均动脉压为50托）时，相同区域顺序的平均脑血流量在0.03至0.10毫升/克/分钟之间。出现低血压时，血流完全停止。放射自显影数据证实了上述发现，并表明脑桥下部有足够的脑血流量。在血管闭塞期间，可能存在足够的脑血流量来维持脑组织，就像在脊髓循环发达或椎动脉意外通畅的动物中一样。
