[Colony-forming capacity of precursor cells of granulomonopoiesis in the liver and spleen at different stages of human embryo- and fetogenesis].

The claster- and colony-forming capacities (CFF) of cells-precursors of granulomonopoiesis (CPGM) in the livers and spleens of 37 human embryos and 9 foetuses were studied in the agar system. The CFC of CPGM in the liver and spleen of 6-8 week old embryos were higher than those during the later embryogenesis. In haemopoietic cell suspension, separated from liver cells, the CFC of CPGM were lower than in the total cell suspension from the liver of 6-8 week old embryos to constant within 6-16 weeks of embryogenesis. The discussion involves stem cell heterogeneity in human embryogenesis, a possible role of the embryonal liver in regulating the number of granulopoietic cells-precursors and their functional activity.