Bretzke G
Z Gesamte Inn Med. 1982 Sep 1;37(17):574-5.
On the basis of 3 observations the author deals with acute ulcers in the oesophagus after oral application of oxytetracycline capsules. Sudden retrosternal pains, beginning in most cases during night, are in the foreground of the clinical picture. Discontinuation of the medicament and prescription of an antacid lead to the regression of the ulcer. For the development of such ulcers probably several factors play a role (pH-changes disturbances of motility and cytolysis). Oxytetracycline capsules should be taken always with abundant fluid and not immediately before bedtime.
基于3例观察结果，作者探讨了口服土霉素胶囊后食管急性溃疡的情况。胸骨后突发疼痛，多数情况下始于夜间，是临床表现的主要特征。停用药物并开具抗酸剂可使溃疡消退。此类溃疡的发生可能有多种因素起作用（pH值变化、动力障碍和细胞溶解）。服用土霉素胶囊时应始终饮用足量液体，且不要在临睡前立即服用。
