Heliövaara M, Karvonen M J, Punsar S, Haapakoski J
Am J Cardiol. 1982 Dec;50(6):1248-52. doi: 10.1016/0002-9149(82)90457-x.
Smoking history, systolic blood pressure, and serum cholesterol concentration were studied for their value in predicting 5-year coronary mortality in middle-aged and older Finnish men. Total experience consisted of 188 deaths from ischemic heart disease during 20,245 person-years. Initially, the men were divided into 3 groups according to the degree of myocardial ischemia: (1) previous myocardial infarction; (2) ischemic heart disease without infarction; and (3) no myocardial ischemia. The 3 main risk factors were associated, independently of each other and of age, with the relative risk of coronary death similarly in the 3 groups, whereas their absolute impact on mortality was strong among men with ischemic heart disease and even stronger among those with a prior myocardial infarction. For example, the estimated excess coronary mortality attributable to smoking 10 to 19 cigarettes per day was 6.3 deaths per 1,000 person-years in the group with no ischemia, 14.6 in the ischemia group, and 43.1 in the infarction group. The results suggest that secondary prevention of ischemic heart disease may be important. Screening of coronary disease among middle-aged and older men also appears justified.
对吸烟史、收缩压和血清胆固醇浓度进行了研究，以评估它们在预测芬兰中老年男性5年冠心病死亡率方面的价值。总共有20245人年的随访记录，期间发生了188例缺血性心脏病死亡病例。最初，根据心肌缺血程度将男性分为3组：（1）既往心肌梗死；（2）无梗死的缺血性心脏病；（3）无心肌缺血。这3个主要危险因素相互独立且与年龄无关，在3组中与冠心病死亡的相对风险相似，而它们对死亡率的绝对影响在缺血性心脏病男性中较强，在既往有心肌梗死的男性中更强。例如，估计每天吸10至19支烟导致的额外冠心病死亡率在无缺血组为每1000人年6.3例死亡，在缺血组为14.6例，在梗死组为43.1例。结果表明，缺血性心脏病的二级预防可能很重要。对中老年男性进行冠心病筛查似乎也是合理的。
