Takahashi K, Hayafuji C, Murakami N
Am J Physiol. 1982 Dec;243(6):E443-9. doi: 10.1152/ajpendo.1982.243.6.E443.
Free-running patterns of blood corticosterone rhythm were examined between the fourth and eighth postnatal week in blinded pups optically enucleated on day 1. When blinded pups were raised by intact natural mothers, the peak time of corticosterone rhythm appeared near the time of light-dark (LD) transition, which was close to that of mothers, and then free-ran. This phase relation between mothers and pups showed that mothers entrained pups' corticosterone rhythm. When blinded pups born of LD (or DL) mothers were raised by DL (or LD) foster mothers, the corticosterone rhythm in blinded pups was close to that of foster mothers at 4 wk of age, indicating that a foster mother plays a predominant role in entraining the pups' rhythm. When blinded pups were raised by blinded mothers whose rhythm was out of phase of the lighting cycle, pups' rhythm was in phase with that of mothers, showing that lighting cycle did not affect the pups' rhythm. These facts indicate that the mother nursing pups acts as the most predominant entrainer of corticosterone rhythm of the blinded pups.
在出生后第1天进行光学摘除眼球的盲幼崽中，研究了出生后第4周和第8周期间血皮质酮节律的自主运行模式。当盲幼崽由完整的自然母亲抚养时，皮质酮节律的峰值时间出现在明暗（LD）转换时间附近，这与母亲的时间相近，然后自主运行。母亲和幼崽之间的这种相位关系表明母亲夹带了幼崽的皮质酮节律。当由LD（或DL）母亲所生的盲幼崽由DL（或LD）代养母亲抚养时，4周龄时盲幼崽的皮质酮节律与代养母亲的节律相近，这表明代养母亲在夹带幼崽节律方面起主要作用。当盲幼崽由节律与光照周期不同步的盲母亲抚养时，幼崽的节律与母亲的节律同步，这表明光照周期不影响幼崽的节律。这些事实表明，哺乳幼崽的母亲是盲幼崽皮质酮节律最主要的夹带者。
