Kraus G, Taeger K
Anasth Intensivther Notfallmed. 1982 Sep;17(5):285-9.
To induce anaesthesia, 100 children between 18 months and 7 years of age who had been selected for surgery or invasive diagnosis, received a 10% methohexitone solution in a dosage of 20-30 mg/kg body weight by rectal instillation. The time until onset of sleep, the pulse rate and blood pressure changes, duration of operation, recovery time and any special observations were recorded. Methohexitone concentrations in the plasma were measured in 7 children during rectal induction of anaesthesia. It was found that induction of anaesthesia in children by rectal application of 20-30 mg/kg body weight methohexitone is a safe procedure which does not cause discomfort to the children and is easily handled by the physician. The methohexitone levels in the plasma are not higher than those after intravenous administration.
为诱导麻醉,选取100名年龄在18个月至7岁之间、已被选定进行手术或侵入性诊断的儿童,通过直肠滴注给予10%美索比妥溶液,剂量为20 - 30毫克/千克体重。记录入睡时间、脉搏率和血压变化、手术持续时间、恢复时间以及任何特殊观察结果。在7名儿童直肠诱导麻醉期间测定了血浆中美索比妥的浓度。结果发现,通过直肠给予20 - 30毫克/千克体重的美索比妥对儿童进行麻醉诱导是一种安全的方法,不会给儿童带来不适,且医生操作简便。血浆中美索比妥水平不高于静脉给药后的水平。