Fitzpatrick J H, Gilboe D D
Anesthesiology. 1982 Dec;57(6):480-4. doi: 10.1097/00000542-198212000-00008.
Nitrous oxide has been reported to act both as a stimulant and as a depressant of cerebral oxygen metabolism (CMRO2) and blood flow under a variety of experimental conditions in the intact animal. The isolated brain preparation is advantageous because it permits direct measurement of blood flow and allows the study of drug effects without interference from other organ systems or drugs. In this study, six isolated perfused canine brain preparations were used to compare the CMRO2, cerebral vascular resistance (CVR), and the EEG of brains perfused with normocapnic, normoxic blood equilibrated with either 70% N2O or 70% N2. There was no significant change in CMRO2. Cerebral vascular resistance fell [16.4% +/- 3.4% SEM (P less than 0.015)] during exposure to N2O. The EEG pattern was reduced in amplitude, but showed an increase in both low-voltage beta activity (14-40 Hz), and 3-5 Hz activity. In the isolated brain, N2O reduced cerebral vascular tone while exhibiting no effect on cerebral oxygen metabolism.
据报道，在完整动物的各种实验条件下，一氧化二氮既可以作为脑氧代谢（CMRO2）和血流的刺激剂，也可以作为抑制剂。离体脑制备具有优势，因为它允许直接测量血流，并允许在不受其他器官系统或药物干扰的情况下研究药物作用。在本研究中，使用六个离体灌注犬脑制备物来比较用70% N2O或70% N2平衡的正常碳酸血症、正常氧合血液灌注的脑的CMRO2、脑血管阻力（CVR）和脑电图。CMRO2没有显著变化。在接触N2O期间，脑血管阻力下降[16.4% +/- 3.4% SEM（P小于0.015）]。脑电图模式的振幅降低，但在低压β活动（14 - 40 Hz）和3 - 5 Hz活动方面均有所增加。在离体脑中，N2O降低了脑血管张力，而对脑氧代谢没有影响。
