[Pharmacokinetic interaction of antibiotics and pathogenetic agents in suppurative meningitis].

The effect of the widely used pathogenetic agents, such as detoxicating fluids and diuretics on the pharmacokinetics of antibiotics, i.e. benzylpenicillin, ampicillin and levomycetin was studied. It was shown that infusion of the detoxicating fluids had an effect on the antibiotic blood levels which depended on the volume of the fluid used. The pharmacokinetics of the antibiotics was found to be changed when the antibiotics were used simultaneously with the diuretics. This is of a special importance for documenting the tactics of antibacterial therapy in patients with meningitis complicated by the brain edema, since intensive dehydration therapy is required in such cases. Significant changes in the pharmacokinetic interaction of the antibiotics with different diuretics, i.e. mannitol, lasix and furosemide were demonstrated. Respective recommendations for the medical practice were developed on the basis of this study.