右旋糖酐70是一种淋巴细胞促有丝分裂原吗？

Is dextran 70 a lymphocyte mitogen?

作者信息

Burden A C, Stacey R L, Windle R, Wood R F, Bell P R

出版信息

Lancet. 1977 Oct 1;2(8040):688-9. doi: 10.1016/s0140-6736(77)90498-6.

Abstract

Dextran 70 ('Lomodex') roduced significant increases in thymidine incorporation in a modified whole-blood method of investigating lymphocyte blastogenesis. This blastogenesis occurred at molar concentrations of 7 X 10(-6) and 7 10(-5). At 7 X 10(-7) mol/l dextran alone did not significantly increase thymidine incorporation; however, when this concentration of dextran was added simultaneously with phytohaemagglutinin there was a significant increase in incorporation. Conversely when dextran was added before P.H.A., thymidine incorporation was decreased. These variable effects indicate that dextran 70 may be a B-cell mitogen. Dextran 70 is widely used and these effects on lymphocyte blastogenesis may be clinically relevant.

摘要

在一种用于研究淋巴细胞增殖的改良全血方法中，右旋糖酐70（“Lomodex”）使胸腺嘧啶核苷掺入量显著增加。这种增殖发生在摩尔浓度为7×10⁻⁶和7×10⁻⁵时。在7×10⁻⁷mol/L时，单独的右旋糖酐不会显著增加胸腺嘧啶核苷掺入量；然而，当该浓度的右旋糖酐与植物血凝素同时添加时，掺入量显著增加。相反，当在植物血凝素之前添加右旋糖酐时，胸腺嘧啶核苷掺入量减少。这些不同的效应表明右旋糖酐70可能是一种B细胞促有丝分裂原。右旋糖酐70被广泛使用，其对淋巴细胞增殖的这些效应可能具有临床相关性。