Panush R S, Ossakow S J
Clin Exp Immunol. 1979 Dec;38(3):539-48.
This report describes hitherto unrecognized immunoenhancing properties of acetaminophen on cultured human lymphocytes. The addition of acetaminophen (2.5--300 micrograms/ml) significantly enhanced mitogen-induced blastogenesis. The stimulation of cells by Candida albicans, from individuals who were skin-test positive for antigen and two-way responses of mixed lymphocytes, were similarly augmented. Cells stimulated in the presence of acetaminophen were comparably enhanced in cultures lasting for 24--168 hr. Enhancement of stimulated cells was noted only if the drug was added during the first hours of culture. Exposure of cells to acetaminophen before mitogen stimulation did not enhance responses unless tha cells were simultaneously cultured with mitogen and the drug. Cells obtained from normal subjects before, during and after ingestion of therapeutic amounts of acetaminophen for 3 days, were cultured in a medium without acetaminophen, and did not display increased in vitro responses during or after drug consumption. These data indicated: (1) pharmacological concentrations of acetaminophen significantly enhanced lymphocyte responses to specific, non-specific, soluble and insoluble stimulation in vitro; and (2) enhancement by acetaminophen occurred only when the drug was in contact with cells during the early period of cell activation.
本报告描述了对乙酰氨基酚对培养的人淋巴细胞迄今未被认识的免疫增强特性。添加对乙酰氨基酚（2.5 - 300微克/毫升）可显著增强有丝分裂原诱导的细胞增殖。白色念珠菌对皮肤试验抗原呈阳性个体的细胞刺激以及混合淋巴细胞的双向反应也同样增强。在对乙酰氨基酚存在下刺激的细胞在持续24 - 168小时的培养中得到了类似的增强。仅当在培养的最初几小时内添加药物时才会观察到对刺激细胞的增强作用。在有丝分裂原刺激之前将细胞暴露于对乙酰氨基酚不会增强反应，除非细胞同时与有丝分裂原和药物一起培养。从正常受试者在摄入治疗量的对乙酰氨基酚3天之前、期间和之后获取的细胞，在不含对乙酰氨基酚的培养基中培养，在药物服用期间或之后未显示出体外反应增加。这些数据表明：（1）对乙酰氨基酚的药理浓度在体外显著增强淋巴细胞对特异性、非特异性、可溶性和不溶性刺激的反应；（2）对乙酰氨基酚的增强作用仅在细胞激活早期药物与细胞接触时才会发生。
