用前列腺素F2α处理的大鼠的妊娠与后代情况

Pregnancy and progeny in rats treated with prostaglandin in F2alpha.

作者信息

Persaud T V, Thliveris J A

出版信息

Prostaglandins Med. 1978 Jul;1(1):23-30. doi: 10.1016/0161-4630(78)90073-3.

Abstract

The effects of prostaglandin F2alpha on pregnancy and embryonic development were investigated in pregnant rats. The animals were treated with the prostaglandin at a dose of 50 microgram s.c., on gestational days 9 to 11 or 12 to 15. Compared to the controls, only intrauterine growth was significantly altered. The number of viable offspring recovered near term was not affected by the treatment, and the incidence of fetal resorptions and malformations was not significantly increased when compared with the controls. However, the placenta revealed extensive areas of degeneration that are found in placental insufficiency. Also, the fetal adrenal cortex showed morphological changes indicative of intrauterine distress.

摘要

在怀孕大鼠中研究了前列腺素F2α对妊娠和胚胎发育的影响。在妊娠第9至11天或12至15天，以50微克皮下注射的剂量给动物注射前列腺素。与对照组相比，仅子宫内生长有显著改变。近期回收的存活后代数量不受治疗影响，与对照组相比，胎儿吸收和畸形的发生率没有显著增加。然而，胎盘显示出胎盘功能不全中发现的广泛变性区域。此外，胎儿肾上腺皮质显示出表明子宫内窘迫的形态学变化。