Hilbelink D R, Chen L T, Lanning J C, Persaud T V
Prostaglandins Leukot Med. 1982 Apr;8(4):399-402. doi: 10.1016/0262-1746(82)90063-4.
The influence of PGF2 alpha on pregnancy and fetal outcome was investigated in the hamster. Following subcutaneous treatment with 50, 100, 200, 400, and 800 micrograms PGF2 alpha prenatal loss was significantly increased only at the highest dose level. The offspring of the treated animals were all alive and normal. Fetal weight was not affected. However, following intravenous injection of 100 and 200 micrograms PGF2 alpha there was a significant reduction in fetal weight, and at the 400 micrograms dose level an increase in fetal indicate that PGF2 alpha is not teratogenic in hamsters despite the apparent greater sensitivity of the hamster embryo to prostaglandin.
在仓鼠中研究了前列腺素F2α（PGF2α）对妊娠和胎儿结局的影响。在产前皮下注射50、100、200、400和800微克PGF2α后，仅在最高剂量水平时，产前损失显著增加。接受治疗动物的后代均存活且正常。胎儿体重未受影响。然而，静脉注射100和200微克PGF2α后，胎儿体重显著降低，在400微克剂量水平时胎儿有所增加，这表明尽管仓鼠胚胎对前列腺素的敏感性明显更高，但PGF2α在仓鼠中不具有致畸性。
