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通气后肺的超微结构

Ultrastructure of the lung after ventilation.

作者信息

John E, McDevitt M, Wilborn W, Cassady G

出版信息

Br J Exp Pathol. 1982 Aug;63(4):401-7.

PMID:7150503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2040645/
Abstract

We looked at the ultrastructure of the lung of rabbits ventilated with air moistened with nebulized water ("nebulized group"), and humidified air ("humidified group") compared to a group of controls. Both groups of ventilated rabbits had plasmalemmal vesicles that were larger than in controls. They were fewer in number (P less than 0.001) and less well defined. Early degenerative changes were noted in 6 of 9 rabbits in the nebulized group and 6 of 9 rabbits in the humidified group, while none of the rabbits in the control group were similarly affected. Interstitial oedema of varying severity was seen in 6/9 rabbits from each of the ventilated groups.

摘要

我们观察了用雾化水湿润的空气通气的兔子(“雾化组”)、湿润空气通气的兔子(“湿润组”)的肺超微结构,并与一组对照组进行比较。两组通气兔子的质膜小泡均比对照组的大。其数量较少(P<0.001)且界限欠清晰。雾化组9只兔子中有6只、湿润组9只兔子中有6只出现早期退行性改变,而对照组兔子均未出现类似情况。每个通气组的9只兔子中有6只出现了不同程度的间质性水肿。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8cd/2040645/b9f57bf82721/brjexppathol00106-0055-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8cd/2040645/3e95c90a8987/brjexppathol00106-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8cd/2040645/253492fb32a7/brjexppathol00106-0053-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8cd/2040645/279f205fbc31/brjexppathol00106-0054-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8cd/2040645/505d92144f8b/brjexppathol00106-0054-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8cd/2040645/b9f57bf82721/brjexppathol00106-0055-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8cd/2040645/3e95c90a8987/brjexppathol00106-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8cd/2040645/253492fb32a7/brjexppathol00106-0053-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8cd/2040645/279f205fbc31/brjexppathol00106-0054-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8cd/2040645/505d92144f8b/brjexppathol00106-0054-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8cd/2040645/b9f57bf82721/brjexppathol00106-0055-a.jpg

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本文引用的文献

1
Effects of gas temperature and particulate water on rabbit lungs during ventilation.通气过程中气体温度和颗粒水对兔肺的影响。
Pediatr Res. 1980 Nov;14(11):1186-91. doi: 10.1203/00006450-198011000-00007.
2
Effects of intermittent positive-pressure ventilation on lungs of normal rabbits.间歇性正压通气对正常家兔肺部的影响。
Br J Exp Pathol. 1980 Jun;61(3):315-23.
3
Electron microscopic alterations at the alveolar level in pulmonary edema.肺水肿时肺泡水平的电子显微镜下改变
Am J Physiol Lung Cell Mol Physiol. 2013 Oct 1;305(7):L478-84. doi: 10.1152/ajplung.00437.2012. Epub 2013 Aug 30.
4
Toxicity of prolonged high dose inhaled PGE1 in ventilated neonatal pigs.长时间高剂量吸入PGE1对机械通气新生猪的毒性作用
Pulm Pharmacol Ther. 2008;21(3):565-72. doi: 10.1016/j.pupt.2008.01.011. Epub 2008 Feb 6.
5
Hypercapnic acidosis impairs plasma membrane wound resealing in ventilator-injured lungs.高碳酸血症性酸中毒会损害机械通气所致肺损伤中质膜伤口的重新愈合。
Am J Respir Crit Care Med. 2005 Jun 15;171(12):1371-7. doi: 10.1164/rccm.200309-1223OC. Epub 2005 Feb 1.
6
Cellular stress failure in ventilator-injured lungs.呼吸机所致肺损伤中的细胞应激性衰竭
Am J Respir Crit Care Med. 2005 Jun 15;171(12):1328-42. doi: 10.1164/rccm.200408-1036SO. Epub 2005 Feb 1.
7
Eight hours' inhalation of prostacyclin (PGI2) in healthy lambs: effects on tracheal, bronchial, and alveolar morphology.健康羔羊吸入前列环素(PGI2)八小时:对气管、支气管及肺泡形态的影响。
Intensive Care Med. 1996 Nov;22(11):1232-8. doi: 10.1007/BF01709341.
8
Lung injury and repair in rabbits from ventilation with moist air.湿润空气通气对家兔肺损伤及修复的影响
Br J Exp Pathol. 1989 Dec;70(6):637-45.
Circ Res. 1967 Dec;21(6):783-97. doi: 10.1161/01.res.21.6.783.
4
Pulmonary lesions associated with oxygen therapy and artificial ventilation.与氧疗和人工通气相关的肺部病变
N Engl J Med. 1967 Feb 16;276(7):368-74. doi: 10.1056/NEJM196702162760702.
5
Lung injury from oxygen in lambs: the role of artificial ventilation.
Anesthesiology. 1969 Jun;30(6):609-18. doi: 10.1097/00000542-196906000-00007.
6
Ultrastructural changes in pulmonary oedema produced experimentally with ammonium sulphate.硫酸铵实验性诱导产生的肺水肿的超微结构变化
J Pathol. 1970 Apr;100(4):281-6. doi: 10.1002/path.1711000407.
7
Interstitial pulmonary edema. An electron microscopic study of the pathology of staphylococcal enterotoxemia in Rhesus monkeys.间质性肺水肿。恒河猴葡萄球菌肠毒素血症病理学的电子显微镜研究。
Lab Invest. 1967 Jun;16(6):912-24. doi: 10.21236/ad0811615.
8
Experimental pulmonary edema due to intermittent positive pressure ventilation with high inflation pressures. Protection by positive end-expiratory pressure.高充气压力间歇性正压通气所致实验性肺水肿。呼气末正压的保护作用。
Am Rev Respir Dis. 1974 Nov;110(5):556-65. doi: 10.1164/arrd.1974.110.5.556.
9
[Pulmonary damage following assisted ventilation and oxygenotherapy in the cat (author's transl)].猫辅助通气和氧疗后的肺损伤(作者译)
Respiration. 1977;34(5):278-84. doi: 10.1159/000193837.
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Lung surfactant and the pathogenesis of neonatal bronchiolar lesions induced by artificial ventilation.肺表面活性物质与人工通气所致新生儿细支气管病变的发病机制
Pediatr Res. 1978 Apr;12(4 Pt 1):249-55. doi: 10.1203/00006450-197804000-00001.