Todd D A, John E
Department of Paediatrics, Westmead Hospital, NSW, Australia.
Br J Exp Pathol. 1989 Dec;70(6):637-45.
We pursued previous studies on acute and later effects of different forms of humidification on rabbits' lungs during respiratory support. Arterial wall thickening and alveolar membrane damage was confirmed in the presence of water in the inspired gas. Interstitial collagen was significantly increased 2 weeks later. Though independent of the kind of respiratory support the findings were more pronounced with positive pressure ventilation than with a low continuous pressure with spontaneous breathing. These effects did not occur after humidification with precautions against condensation, and were thus attributable to particulate water. They were interpreted as evidence for lung injury and subsequent repair from this cause. Increased width of small artery walls, possibly from vasoconstriction, was similarly related.
我们继续进行了之前关于不同形式的湿化对呼吸支持期间家兔肺部急性和后续影响的研究。在吸入气体中存在水分的情况下，证实了动脉壁增厚和肺泡膜损伤。两周后，间质胶原显著增加。尽管这些发现与呼吸支持的类型无关，但在正压通气时比在低持续压力下自主呼吸时更为明显。在用防止冷凝的措施进行湿化后，这些影响并未出现，因此可归因于颗粒状水。它们被解释为由该原因导致的肺损伤及后续修复的证据。小动脉壁宽度增加，可能是由于血管收缩，情况与此类似。
