Herbertson B M, King A J, Allen J
Br J Exp Pathol. 1982 Dec;63(6):594-605.
The tritiated thymidine labelling index (LI) of the epithelium of the ureters and urinary bladder of young male Wistar rats is substantially increased 18 h after a simple laparotomy incision. A similar highly significant increase (P less than 0.001) has been observed after a single i.p. injection of various materials, including (a) distilled water, (b) 0.5% glycogen in physiological saline, and (c) 1% suspension of lycopodium spores in physiological saline. In each instance an aseptic inflammatory response develops in the peritoneal cavity. Reasons are given supporting the concept that a mitogen is produced from a constituent of the inflammatory exudate in the peritoneal cavity and that the factor reaches the affected epithelium by direct diffusion.
年轻雄性Wistar大鼠输尿管和膀胱上皮的氚标记胸腺嘧啶核苷标记指数（LI）在单纯剖腹手术后18小时显著升高。在单次腹腔注射各种物质后也观察到类似的高度显著升高（P<0.001），这些物质包括：（a）蒸馏水，（b）生理盐水中0.5%的糖原，以及（c）生理盐水中1%的石松子孢子悬液。在每种情况下，腹腔内都会发生无菌性炎症反应。文中给出了理由支持这样的观点：有丝分裂原是由腹腔内炎性渗出物的一种成分产生的，并且该因子通过直接扩散到达受影响的上皮。
