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通过膀胱内灌注蒸馏水刺激大鼠膀胱上皮细胞DNA合成。

Stimulation of rat bladder epithelial DNA synthesis by intravesical instillation of distilled water.

作者信息

Ozono S, Lee I C, Weinstein R S, Oyasu R

出版信息

Proc Soc Exp Biol Med. 1986 Jul;182(3):325-7. doi: 10.3181/00379727-182-42347.

DOI:10.3181/00379727-182-42347
PMID:3714713
Abstract

Two commonly used cystoscopic infusion fluids were examined to determine whether their infusion stimulates DNA synthesis of the bladder epithelium. Following a single intravesical dose of 0.5 ml of distilled water or 1.5% L-glycine solution, rats were killed periodically up to 1 week. A transient but significant increase in epithelial cell [3H]thymidine labeling was observed at 48 hr after distilled water instillation. Glycine solution did not stimulate DNA synthesis.

摘要

对两种常用的膀胱镜检查灌注液进行了检测,以确定它们的灌注是否会刺激膀胱上皮细胞的DNA合成。给大鼠膀胱内单次注射0.5毫升蒸馏水或1.5%的L-甘氨酸溶液后,在长达1周的时间内定期处死大鼠。蒸馏水灌注后48小时,观察到上皮细胞[3H]胸腺嘧啶核苷标记有短暂但显著的增加。甘氨酸溶液未刺激DNA合成。

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