Wirtz P, Loermans H, Rutten E
Br J Exp Pathol. 1982 Dec;63(6):671-9.
Irradiation of dystrophic mouse (strain Re 129) leg muscles with a single dose of 20 Gy 10 days after birth resulted in subtotal suppression of regeneration. One week after the treatment regenerating muscle cells were scarce, while in the contralateral untreated leg the process of regeneration was unhampered. Here, numerous young muscle cells were a striking feature. The model is used to examine the processes of fibre wasting and regeneration, and to investigate their effects on the development of the dystrophic syndrome.
出生后10天对营养不良小鼠(Re 129品系)腿部肌肉进行单次20 Gy的照射,导致再生几乎完全受到抑制。治疗一周后,再生的肌肉细胞很少,而对侧未治疗的腿部再生过程未受阻碍。在此,大量年轻的肌肉细胞是一个显著特征。该模型用于研究纤维萎缩和再生过程,并探讨它们对营养不良综合征发展的影响。