前列腺素E1增强苯巴比妥对大鼠的抗惊厥作用。脑单胺的作用

Prostaglandin E1-induced potentiation of the anticonvulsant action of phenobarbitone in the rat. Role of brain monoamines.

作者信息

Bhattacharya S K, Sanyal A K

出版信息

Prostaglandins Med. 1978 Aug;1(2):159-64. doi: 10.1016/0161-4630(78)90042-3.

Abstract

Prostaglandin E1 (PGE1) significantly potentiated the anticonvulsant action of a sub-effective (EDO) dose of phenobarbitone, against maximal electroshock-induced seizures in the rat. PGE1-induced potentiation of phenobarbitone was significantly inhibited after pretreatment with drugs which are known to reduce brain serotonin activity, but was unaffected by drugs known to decrease brain catecholamine activity. Prostaglandin F2 alpha produced a moderate though statistically insignificant inhibition of PGE1 effect. The results suggest that PGE1-induced potentiation of phenobarbitone is not a direct effect but an indirect one, mediated through an increase in brain serotonin activity.

摘要

前列腺素E1（PGE1）能显著增强低于有效剂量（EDO）的苯巴比妥对大鼠最大电休克诱发惊厥的抗惊厥作用。在用已知能降低脑血清素活性的药物预处理后，PGE1诱导的苯巴比妥增强作用受到显著抑制，但不受已知能降低脑儿茶酚胺活性的药物影响。前列腺素F2α对PGE1的作用产生了适度但在统计学上无显著意义的抑制。结果表明，PGE1诱导的苯巴比妥增强作用不是直接作用，而是通过脑血清素活性增加介导的间接作用。