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Inhibition of pentylenetetrazol-induced convulsions in rats by prostaglandin E1: role of brain monoamines.

作者信息

Bhattacharya S K, Sanyal A K

出版信息

Psychopharmacology (Berl). 1978 Mar 1;56(2):235-7. doi: 10.1007/BF00431857.

DOI:10.1007/BF00431857
PMID:417379
Abstract

Prostaglandin E1-(PGE1-) induced inhibition of pentylenetetrazol (PTZ) convulsions in rats were significantly antagonized after pretreatment with drugs known to reduce brain serotonin activity, but not by pharmacological agents that decrease brain catecholamine activity. PGF2alpha also significantly inhibited PGE1 action. The results suggest that PGE1-induced inhibition of PTZ convulsions is not a direct effect, but an indirect one mediated through increase in brain serotonin activity.

摘要

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本文引用的文献

1
Inhibitors of endogenous catecholamine biosynthesis.内源性儿茶酚胺生物合成抑制剂。
Pharmacol Rev. 1966 Mar;18(1):599-609.
2
p-Chlorophenylalanine: a specific depletor of brain serotonin.对氯苯丙氨酸：一种脑血清素的特异性耗竭剂。
J Pharmacol Exp Ther. 1966 Dec;154(3):499-516.
3
Long-lasting selective depletion of brain serotonin by 5,6-dihydroxytryptamine.5,6-二羟基色胺对脑血清素的长期选择性耗竭。
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Psychopharmacology (Berl). 1983;80(4):365-70. doi: 10.1007/BF00432122.
4
Prostaglandin D2 inhibits pentylenetetrazole-induced convulsions in rats by a serotonin-mediated mechanism.前列腺素D2通过5-羟色胺介导的机制抑制大鼠戊四氮诱发的惊厥。
Pharm Res. 1987 Oct;4(5):406-8. doi: 10.1023/a:1016486329226.
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Central monoamines and convulsine thresholds in mice and rats.小鼠和大鼠体内的中枢单胺类物质与惊厥阈值
Neuropharmacology. 1973 Jul;12(7):681-92. doi: 10.1016/0028-3908(73)90121-4.
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Histochemical amd biochemical effects of diethyldithiocarbamate on tissue catecholamines.二乙基二硫代氨基甲酸盐对组织儿茶酚胺的组织化学和生物化学作用。
J Pharm Pharmacol. 1966 Jan;18(1):60-2. doi: 10.1111/j.2042-7158.1966.tb07773.x.
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Prostaglandins and the central nervous system.前列腺素与中枢神经系统
Arch Intern Med. 1974 Jan;133(1):119-29.
7
Prostaglandin E1 causes sedation and increases 5-hydroxytryptamine turnover in rat brain.前列腺素E1可引起大鼠大脑镇静并增加5-羟色胺的更新率。
Br J Pharmacol. 1973 May;48(1):80-7. doi: 10.1111/j.1476-5381.1973.tb08224.x.
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Prostaglandins: antinociceptive effect of prostaglandin E1 in the rat.
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Prostaglandins: effect of prostaglandin E1 on brain, stomach and intestinal serotonin in rat.前列腺素：前列腺素E1对大鼠脑、胃及肠道5-羟色胺的影响
Biochem Pharmacol. 1978 Jan 1;27(1):130-2. doi: 10.1016/0006-2952(78)90272-1.
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Role of 5-hydroxytryptamine in prostaglandin E1-induced potentiation of hexobarbitone hypnosis in albino rats.
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