Horrobin D F, Karmali R A, Manku M S, Ally A I, Morgan R O, Cunnane S C, Karmazyn M
Prostaglandins Med. 1978 Aug;1(2):175-81. doi: 10.1016/0161-4630(78)90045-9.
A failure of thromboxane (TX) A2 synthesis may be a factor in cancer. Such a loss could explain the susceptibility to mutation, the excess prostaglandin production, the glycolytic mode of metabolism and the deranged calcium pumping characteristic of cancers. Ionising radiation and phorbols both have actions similar to inhibitors of TXA2 synthesis whereas colchicine and oxygen have actions consistent with stimulation of TXA2 synthesis. The concept accounts logically for hitherto unexplained features of cancer and suggests new strategies for the prevention and treatment of cancer.
血栓素（TX）A2合成失败可能是癌症的一个因素。这种缺失可以解释癌症对突变的易感性、前列腺素的过量产生、糖酵解代谢模式以及癌症特有的钙泵功能紊乱。电离辐射和佛波酯都具有与TX A2合成抑制剂相似的作用，而秋水仙碱和氧气的作用则与刺激TX A2合成一致。这一概念从逻辑上解释了癌症迄今无法解释的特征，并为癌症的预防和治疗提出了新的策略。
