早产儿透明膜病中循环前列腺素浓度的选择性升高。

Selective elevation of circulating prostaglandin concentrations in hyaline membrane disease in pre-term infants.

作者信息

Mitchell M D, Lucas A, Whitfield M, Etches P, Brunt J D, Turnbull A C

出版信息

Prostaglandins Med. 1978 Sep;1(3):207-12. doi: 10.1016/0161-4630(78)90107-6.

Abstract

The plasma concentrations of prostaglandins E and F (PGE, PGF) and 13, 14-dihydro-15-keto-PGF (PGFM) have been measured in pre-term neonates with hyaline membrane disease (HMD) and controls. The concentrations of PGF and PGFM were significantly higher in infants having HMD with a disproportionate increase in PGFM levels for the increase in PGF found. The vasoconstrictor nature of PGF may contribute to the morbidity associated with HMD and the possible therapeutic benefit from the use of prostaglandin synthetase inhibitors is discussed.

摘要

在患有透明膜病（HMD）的早产儿和对照组中，已对前列腺素E和F（PGE、PGF）以及13,14-二氢-15-酮-PGF（PGFM）的血浆浓度进行了测量。患有HMD的婴儿中PGF和PGFM的浓度显著更高，且PGFM水平的升高与PGF的升高不成比例。PGF的血管收缩特性可能导致与HMD相关的发病率，文中还讨论了使用前列腺素合成酶抑制剂可能带来的治疗益处。