低出生体重儿的动脉导管未闭
Patent ductus arteriosus in infants of low birth weight.
作者信息
Smith D R, Cook D H, Izukawa T, Olley P M, Swyer P R, Rowe R D
出版信息
Can Med Assoc J. 1980 Oct 18;123(8):739-44.
Patent ductus arteriosus was diagnosed in 239 neonates of low birth weight (less than 2500 g) referred to the Hospital for Sick Children in a 21/2-year period. The respiratory distress syndrome was present in 77% of the group and congestive heart failure in 50%. Spontaneous closure of the defect was more frequent in those without congestive heart failure. In 48 patients whose heart failure could not be controlled by other medical therapy indomethacin was given, and in 20 (42%) it was judged successful. Surgical ligation of the ductus was performed at a median age of 30 days in 33 infants who either failed to respond to indomethacin or in whom its use was contraindicated; there were no intraoperative deaths, but 11 (33%) of the infants died 4 days to 6 months after the operation.
在两年半的时间里，转诊至儿童医院的239名低体重（小于2500克）新生儿被诊断为动脉导管未闭。该组中77%的患儿出现呼吸窘迫综合征，50%的患儿出现充血性心力衰竭。在没有充血性心力衰竭的患儿中，缺损自发闭合更为常见。48例心力衰竭无法通过其他药物治疗控制的患儿接受了吲哚美辛治疗，其中20例（42%）被判定治疗成功。33例对吲哚美辛无反应或使用吲哚美辛有禁忌证的婴儿在中位年龄30天时进行了动脉导管结扎术；术中无死亡病例，但11例（33%）婴儿在术后4天至6个月死亡。
Zotero 插件