围产期山羊对前列腺素前体的循环反应。

Circulatory responses of perinatal goats to prostaglandin precursors.

作者信息

Tyler T L, Leffler C W, Cassin S

出版信息

Prostaglandins Med. 1978 Sep;1(3):213-29. doi: 10.1016/0161-4630(78)90108-8.

Abstract

The effects of precursors in the prostaglandin synthetic pathway as well as those of analogs of cyclic endoperoxide intermediates upon the pulmonary and systemic circulations of fetal and newborn goats were examined. Exogenous arachidonic acid increased pulmonary vascular resistance and decreased systemic arterial pressure of fetuses and newborns. The effects of dihomo-gamma-linolenic acid on the circulation are qualitatively similar, but quantitatively less, than those of arachidonic acid. The cyclic endoperoxide analogs were strong pressors in both pulmonary and systemic circulations. The responses to the fatty acid precursors, which are totally blocked by indomethacin and meclofenamate, appear to indicate that they give rise to more than one vasoactive product. Furthermore, exogenous arachidonic acid produces effects which appear to be different from those produced by endogenous pulmonary arachidonic acid.

摘要

研究了前列腺素合成途径中的前体以及环内过氧化物中间体类似物对胎羊和新生羊肺循环和体循环的影响。外源性花生四烯酸增加了胎儿和新生儿的肺血管阻力并降低了体动脉血压。二高-γ-亚麻酸对循环的影响在性质上与花生四烯酸相似，但在数量上较小。环内过氧化物类似物在肺循环和体循环中都是强效升压剂。对脂肪酸前体的反应完全被吲哚美辛和甲氯芬那酸阻断，这似乎表明它们会产生不止一种血管活性产物。此外，外源性花生四烯酸产生的效应似乎与内源性肺花生四烯酸产生的效应不同。