Chusova G G, Ostapenko I A, Shabanova M E, Eliseeva R F
Biull Eksp Biol Med. 1982 Nov;94(11):21-3.
The content of uric acid was measured in the blood of patients suffering from retinitis pigmentosa, as well as in the blood, retina, brain, liver and urine of rats with inherited retinal degeneration in the course of postnatal development. It was found that in the patients with retinitis pigmentosa, the concentration of uric acid in the blood serum was 50% higher as compared to normals. On the 8th day of life the content of uric acid in the blood of the sick rats was equal to 150% as compared to the normal animals. This difference persisted during the subsequent postnatal life. In the rats with inherited retinal degeneration, the content of this purine in the retina, brain and liver was approximately the same as that seen in the normal animals in all the studied periods of life. Meanwhile statistically significant changes in the uric acid content in the sick animals' urine appeared at an age of 1.5-2 months. It is believed that the identical line of changes in the uric acid content in the blood of the sick persons and rats points to similarity of the experimental disease of the animals to the disease in humans.
对患有色素性视网膜炎患者的血液以及在出生后发育过程中患有遗传性视网膜变性的大鼠的血液、视网膜、大脑、肝脏和尿液中的尿酸含量进行了测定。结果发现，色素性视网膜炎患者血清中的尿酸浓度比正常人高50%。在出生后第8天，患病大鼠血液中的尿酸含量与正常动物相比达到150%。这种差异在出生后的后续生命过程中一直存在。在患有遗传性视网膜变性的大鼠中，在所有研究的生命阶段，视网膜、大脑和肝脏中这种嘌呤的含量与正常动物大致相同。与此同时，患病动物尿液中尿酸含量在1.5 - 2个月龄时出现了具有统计学意义的变化。据信，患病者和大鼠血液中尿酸含量相同的变化趋势表明动物的实验性疾病与人类疾病具有相似性。
