Bui N B, Marit G, Albin H, Durand M, Mauriac L, Hoerni B
Bull Cancer. 1982;69(4):330-5.
From november 1981 to january 1982, 80 consecutive patients received high dose metoclopramide, adjoined to different cancer chemotherapy regimens containing cisplatine, dacarbazine, actinomycin D or mithramycin. Nineteen of them (23,75%) had no chemotherapy induced nausea or vomiting, 30 (37,5%) had nausea alone or vomited only once, and 17 (21,3%) had 3 to 5 episodes of vomiting. The overall efficacy of high-dose metoclopramide was 83,7 per cent. It has been seen whatever the chemotherapeutic agents used, and was inchanged for the following courses in 33 of 37 patients who received 2 to 4 courses. In 25 out of 33 patients who had already received the same chemotherapy without high dose metoclopramide, the digestive tolerance have been improved by the antiemetic treatment. Toxicity of high dose metoclopramide had been encountered in 17 (21,5%) of the patients and necessited this treatment to be stopped in 10. There were mainly extrapyramidal syndroms, diarrhea and drownsiness. The toxicity of high dose metoclopramide was of concern mainly in patients younger than 30, and/or when dosage escalation have been attempted.
1981年11月至1982年1月，80例连续患者接受了大剂量甲氧氯普胺治疗，这些患者同时接受了包含顺铂、达卡巴嗪、放线菌素D或光辉霉素的不同癌症化疗方案。其中19例（23.75%）没有化疗引起的恶心或呕吐，30例（37.5%）仅有恶心或仅呕吐一次，17例（21.3%）有3至5次呕吐发作。大剂量甲氧氯普胺的总体有效率为83.7%。无论使用何种化疗药物，均观察到该疗效，并且在接受2至4个疗程的37例患者中的33例中，后续疗程疗效未改变。在33例之前接受过相同化疗但未使用大剂量甲氧氯普胺的患者中，有25例的消化耐受性通过止吐治疗得到改善。17例（21.5%）患者出现了大剂量甲氧氯普胺的毒性反应，其中10例需要停止该治疗。主要为锥体外系综合征、腹泻和嗜睡。大剂量甲氧氯普胺的毒性主要在30岁以下患者和/或尝试增加剂量时受到关注。
