Hornsey S, Myers R, Warren P
Br J Radiol. 1982 Jul;55(655):516-9. doi: 10.1259/0007-1285-55-655-516.
Residual injury in the spinal cord 100 days after X rays or neutrons was measured by the reduction in dose of a second radiation required to produce nerve damage assessed by the development of ataxia within the first post-irradiation year. Between 5-10% residual damage was observed after X-ray doses of 25% or 50% of the single X-ray dose which produced ataxia in 50% of animals (ED50), but 30% residual injury was observed if the X-ray dose was 75% of the ED50 dose. Neutron doses of 25% and 50% of the ED50 neutron dose gave the same level of residual injury as observed after equivalent X-ray doses, indicating that for this type of damage the shedding of residual damage was similar after X rays or neutrons. More residual damage is observed after a dose of X rays for vascular related damage than for damage associated with glial cell loss. However, if residual damage is expressed in terms of the relevant vascular or glial cell damage caused by the priming dose the same relationship between primary damage and residual damage is seen for both glial and vascular related damage.
通过在照射后第一年内出现共济失调来评估神经损伤，进而测量产生该损伤所需的第二次辐射剂量的减少量，以此来测定X射线或中子照射脊髓100天后的残留损伤。在产生50%动物共济失调的单次X射线剂量（ED50）的25%或50%的X射线剂量照射后，观察到5%-10%的残留损伤，但如果X射线剂量为ED50剂量的75%，则观察到30%的残留损伤。ED50中子剂量的25%和50%所产生的残留损伤水平与同等X射线剂量照射后观察到的相同，这表明对于这种类型的损伤，X射线或中子照射后残留损伤的消除情况相似。与胶质细胞损失相关的损伤相比，血管相关损伤在接受一定剂量X射线照射后观察到更多的残留损伤。然而，如果残留损伤以引发剂量所导致的相关血管或胶质细胞损伤来表示，那么对于胶质细胞和血管相关损伤，原发性损伤与残留损伤之间都呈现相同的关系。
