Schoeters G E
Br J Radiol. 1982 Jul;55(655):520-9. doi: 10.1259/0007-1285-55-655-520.
A method of determining local radiation doses from 226Ra to selected bone marrow sites of 226Ra-injected mice is presented. The 226Ra burden in selected cortical and trabecular bone sites of BALB/c mice and the morphometric characteristics of these bone sites and of their marrow cavities in BALB/c mice are measured. These data, along with information on dosimetry from the literature, are used to calculate the cumulative dose in the selected bone and marrow cavity sites. The amount of 226Ra picked up by a bone is shown to be linearly related to the area of bone surface. The energy absorption in various bone and bone marrow sites is not homogeneous. The relationship between local marrow doses and the observed non-uniformity in damage to haemopoietic marrow cells of different marrow sites 300 days after 226Ra injection is discussed. The degree of marrow damage does not simply reflect the calculated marrow dose. This dose-effect study gives some indications for (1) a modification of the approach used in local 226Ra dosimetry and (2) additional damage to the stem cells due to irradiation of their regulating system.
本文提出了一种确定226Ra注入小鼠后选定骨髓部位局部辐射剂量的方法。测量了BALB/c小鼠选定皮质骨和小梁骨部位的226Ra负荷以及这些骨部位及其骨髓腔的形态特征。这些数据与文献中的剂量学信息一起，用于计算选定骨和骨髓腔部位的累积剂量。研究表明，骨摄取的226Ra量与骨表面积呈线性关系。不同骨和骨髓部位的能量吸收并不均匀。讨论了局部骨髓剂量与226Ra注射300天后不同骨髓部位造血骨髓细胞损伤的观察到的不均匀性之间的关系。骨髓损伤程度并不简单地反映计算出的骨髓剂量。这项剂量效应研究为(1)修改局部226Ra剂量测定中使用的方法和(2)由于其调节系统的照射对干细胞造成的额外损伤提供了一些指示。
