Thompson P M, Pryor J P, Williams J P, Eyers D E, Dulake C, Scully M F, Kakkar V V
Br J Urol. 1982 Dec;54(6):736-40. doi: 10.1111/j.1464-410x.1982.tb13637.x.
The incidence of infection after needle biopsy of the prostate by different techniques was compared in 45 patients. Aerobic and anaerobic culture was made of the biopsy needle, prostate, urine and blood. In addition, endotoxin assays were determined by a new chromogenic method using Limulus lysate. All of the patients undergoing transrectal biopsy were found to have a bacteraemia; 27% were symptomatic and 87% had a post-operative urinary tract infection. A double-blind controlled trial using cefamandole with the premedication showed a significant reduction in the incidence of bacteraemia to 53% and the prevention of a urinary tract infection. Following transperineal biopsy, although the incidence of bacteraemia was 40% and urinary tract infection 27%, none of these patients was symptomatic and the organisms causing the bacteraemia were predominantly skin contaminants. The endotoxin assays showed differences between the groups with higher endotoxin values in the unprotected transrectal group.
对45例患者采用不同技术进行前列腺穿刺活检后的感染发生率进行了比较。对活检针、前列腺、尿液和血液进行需氧和厌氧培养。此外，采用一种新的使用鲎试剂的显色法测定内毒素。所有接受经直肠活检的患者均出现菌血症；27%有症状，87%有术后尿路感染。一项使用头孢孟多并进行术前用药的双盲对照试验显示，菌血症发生率显著降低至53%，并预防了尿路感染。经会阴活检后，虽然菌血症发生率为40%，尿路感染发生率为27%，但这些患者均无症状，引起菌血症的微生物主要是皮肤污染物。内毒素检测显示不同组之间存在差异，未受保护的经直肠组内毒素值较高。
