Meyerson B J
Brain Res. 1982 Dec 16;253(1-2):281-6. doi: 10.1016/0006-8993(82)90695-3.
A study was made of the effect of colchicine on the lordotic response to estradiol benzoate (EB) plus progesterone in ovariectomized rats. Colchicine (0.5 + 0.25 mg/kg s.c.) given in connection with the EB treatment inhibited the response elicited by progesterone 24 or 48 h after administration of EB. In contrast, significantly more colchicine-treated animals responded when progesterone was given at 118 h. This increase in lordotic response occurred at a time when normally the response has declined. The response was not enhanced by the protein synthesis inhibitors anisomycin (50 mg/kg s.c.) or cycloheximide (1 mg/kg s.c.). The results suggest that an impairment of axonal transport by colchicine may lead to storage of lordosis-promoting products, which are released when the colchicine effect has worn off.
研究了秋水仙碱对去卵巢大鼠中苯甲酸雌二醇（EB）加孕酮所致脊柱前凸反应的影响。在给予EB治疗时皮下注射秋水仙碱（0.5 + 0.25 mg/kg）可抑制EB给药后24或48小时孕酮引发的反应。相反，当在118小时给予孕酮时，经秋水仙碱处理的动物中有显著更多的动物出现反应。这种脊柱前凸反应的增加发生在正常情况下反应已经下降的时候。蛋白质合成抑制剂茴香霉素（50 mg/kg皮下注射）或环己酰亚胺（1 mg/kg皮下注射）并未增强该反应。结果表明，秋水仙碱对轴突运输的损害可能导致促进脊柱前凸的产物储存，当秋水仙碱的作用消退时这些产物会被释放出来。
