Kelsey J E, Belluzzi J D
Brain Res. 1982 Dec 16;253(1-2):337-40. doi: 10.1016/0006-8993(82)90705-3.
Brief electrical stimulation of the enkephalin-rich globus pallidus at 1-h intervals produced kindled, clonic seizures in rats as rapidly as similar stimulation of the amygdala. Massing the kindling trials at 10-min intervals inhibited the occurrence of subsequent seizures, especially following globus pallidus stimulation. Naloxone (20 mg/kg), an opiate receptor antagonist, reversed this post-ictal inhibition of seizures following massed trials, but had no effect on seizures kindled at 1-h intervals. Thus, endorphin-released during seizures do not appear to mediate the production of kindled seizures, but do appear to mediate the transient posts ictal inhibition of seizures.
每隔1小时对富含脑啡肽的苍白球进行短暂电刺激，与对杏仁核进行类似刺激一样，能迅速在大鼠中引发点燃性阵挛性癫痫发作。以10分钟的间隔进行点燃试验聚集抑制了随后癫痫发作的发生，尤其是在苍白球刺激之后。阿片受体拮抗剂纳洛酮（20毫克/千克）逆转了聚集试验后癫痫发作的发作后抑制，但对每隔1小时引发的癫痫发作没有影响。因此，癫痫发作期间释放的内啡肽似乎并不介导点燃性癫痫发作的产生，但似乎确实介导了癫痫发作后的短暂抑制。
