Leadem C A, Blask D E
Cell Tissue Res. 1982;227(2):343-50. doi: 10.1007/BF00210890.
The effects of the pineal gland on the light microscopic-immunocytochemical and ultrastructural appearance of pituitary mammotrophs were studied in female rats eight weeks after prepubertal blinding and olfactory bulbectomy. Blinding and anosmia resulted in a marked decrease in the size of the pars distalis concomitant with a reduction in the apparent number and size of PRL cells as compared with intact animals. Ultrastructurally, these cells appeared much less active than those of intact rats. The small and angular-shaped mammotrophs of blind-anosmic rats characteristically exhibited scant arrays of rough endoplasmic reticulum, small Golgi complexes with few immature secretory granules, few mature secretory granules and rare exocytosis patterns. Pinealectomy tended to reverse the effects of blinding and anosmia on pars distalis size and PRL cell size, apparent number and ultrastructure. In fact, the mammotrophs of blind-anosmic-pinealectomized rats were quite similar in ultrastructural appearance to those of intact rats. From these data we conclude that the pineal causes mammotroph hypotrophy and hypoplasia in blind-anosmic female rats.
在青春期前致盲和切除嗅球8周后的雌性大鼠中，研究了松果体对垂体催乳素细胞的光镜免疫细胞化学和超微结构外观的影响。与完整动物相比，致盲和嗅觉缺失导致远侧部大小显著减小，同时催乳素细胞的表观数量和大小减少。在超微结构上，这些细胞看起来比完整大鼠的细胞活性低得多。盲-嗅觉缺失大鼠的小而呈角形的催乳素细胞的特征是粗面内质网排列稀少，高尔基复合体小，未成熟分泌颗粒少，成熟分泌颗粒少，胞吐模式罕见。松果体切除倾向于逆转致盲和嗅觉缺失对远侧部大小和催乳素细胞大小、表观数量及超微结构的影响。事实上，盲-嗅觉缺失-松果体切除大鼠的催乳素细胞在超微结构外观上与完整大鼠的非常相似。从这些数据我们得出结论，松果体导致盲-嗅觉缺失雌性大鼠的催乳素细胞萎缩和发育不全。
