Yamanouchi K, Watanabe H, Okada R, Arai Y
Endocrinol Jpn. 1982 Aug;29(4):469-74. doi: 10.1507/endocrj1954.29.469.
Relationship between forebrain lordosis inhibiting system and serotonergic mechanism was examined in estradiol benzoate (EB) and progesterone (P)-primed ovariectomized rats. In order to remove the forebrain inhibition of lordosis response, anterior roof deafferentation (ARD) which interrupts the dorsal inputs to the POA coming down anterior to the anterior commissure or medial preoptic area lesions (POA-L) were made. All experimental females pretreated with EB and P showed high levels of lordotic activity. Soon after the behavioral tests, the animals were injected with 10 mg/kg p-chloroamphetamine (PCA) intraperitoneally and tested again 30 min later. PCA strongly suppressed female sexual behavior. Regardless of the presence of ARD or POA-L, no PCA injected females showed lordosis. From these results, it can be said that serotonin may not directly act on the forebrain lordosis inhibiting system.
在接受苯甲酸雌二醇（EB）和孕酮（P）预处理的去卵巢大鼠中，研究了前脑脊柱前凸抑制系统与血清素能机制之间的关系。为了消除前脑对脊柱前凸反应的抑制作用，进行了前顶盖去传入术（ARD），该手术中断了前连合前方下行至视前区（POA）的背侧输入，或制造了内侧视前区损伤（POA-L）。所有用EB和P预处理的实验雌性大鼠均表现出高水平的脊柱前凸活动。行为测试后不久，给动物腹腔注射10mg/kg对氯苯丙胺（PCA），30分钟后再次进行测试。PCA强烈抑制雌性性行为。无论是否存在ARD或POA-L，未注射PCA的雌性大鼠均未表现出脊柱前凸。从这些结果可以看出，血清素可能不会直接作用于前脑脊柱前凸抑制系统。
