年龄会影响氟奋乃静长期给药过程中的多巴胺受体变化。
Age affects dopamine receptor changes during chronic administration of fluphenazine.
作者信息
Misra C H, Shelat H, Smith R C
出版信息
Eur J Pharmacol. 1982 Dec 3;85(3-4):343-6. doi: 10.1016/0014-2999(82)90223-0.
The effects of age on the alteration of brain dopaminergic receptors (spiperone binding) during chronic administration of fluphenazine was studied in young (7-month) and old (25-month) rats. Compared to age-matched saline controls, the old fluphenazine rats showed an earlier on-set and quantitatively greater decrease in specific binding of spiperone and increase in the KD of spiperone binding than young rats. Young rats showed an increase in the Bmax of spiperone binding at 6-weeks which was not shown by old rats.
研究了年龄对氟奋乃静长期给药期间幼龄（7个月）和老龄（25个月）大鼠脑多巴胺能受体（螺哌隆结合）改变的影响。与年龄匹配的生理盐水对照组相比，老龄氟奋乃静大鼠比幼龄大鼠表现出更早出现且螺哌隆特异性结合的定量减少幅度更大，以及螺哌隆结合解离常数（KD）增加。幼龄大鼠在6周时显示出螺哌隆结合最大结合容量（Bmax）增加，而老龄大鼠未出现此现象。
Zotero 插件