Larikova L P, Bershadskiĭ B G, Tsyrlin V A
Farmakol Toksikol. 1982 Nov-Dec;45(6):47-50.
The relationships between initial parameters of systemic hemodynamics, sex and age and the effect of hypotensive drugs were studied in patients with essential hypertension. It was shown that the ability of clonidine to decrease blood pressure is not related to the patients' sex but depends on their age. The relationship was revealed between the initial parameters of the hemodynamics and the effects of propranolol and oxylidin. No such a relationship was demonstrated as regards the effect of aldomet. The effect of propranolol, aldomet and oxylidin on human circulation has not been found to depend either on sex or age.
对原发性高血压患者的全身血流动力学初始参数、性别和年龄与降压药物疗效之间的关系进行了研究。结果表明,可乐定的降压能力与患者性别无关,而取决于患者年龄。血流动力学初始参数与普萘洛尔和氧烯洛尔的疗效之间存在关联。未发现甲基多巴的疗效存在此类关联。未发现普萘洛尔、甲基多巴和氧烯洛尔对人体循环的影响取决于性别或年龄。