Pshenitsin A I, Glotov M N, Mazur N A
Ter Arkh. 1993;65(9):47-50.
Calcium antagonist dilren in a short course was given to 11 hypertensive subjects (AH stage II). A clinical response in the majority of the patients was associated with a decline in systolic, mean arterial and resting diastolic pressure (by 8.1, 7.8 and 11.5%, respectively). In orthostasis and under isometric loading dynamic values of arterial pressure tended to lowering, especially diastolic (by 6.7 and 8.3%, respectively). Reduced pressure resulted from a significant reduction in the total peripheral resistance (by 19.8% at rest, in orthostasis by 10%, in isometric load by 26.1%). Minute blood volume increased because of a rise in stroke output. Dilren is recommended in a standard dose 300 mg/day in mild hypertension and in an individual dose 600 mg/day in moderate disease.
对11名高血压患者（二期高血压）短期给予钙拮抗剂地尔硫䓬。大多数患者的临床反应与收缩压、平均动脉压和静息舒张压下降有关（分别下降8.1%、7.8%和11.5%）。在直立位和等长负荷下，动脉压动态值趋于降低，尤其是舒张压（分别降低6.7%和8.3%）。血压降低是由于总外周阻力显著降低（静息时降低19.8%，直立位时降低10%，等长负荷时降低26.1%）。由于心输出量增加，每分血容量增加。对于轻度高血压，建议使用标准剂量300毫克/天的地尔硫䓬；对于中度高血压，建议使用个体剂量600毫克/天。
