一些新型11-酰基-5,11-二氢-6H-吡啶并[2,3-b][1,4]苯并二氮杂卓-6-酮的合成与性质
Synthesis and properties of some new 11-acyl-5,11-dihydro-6H-pyrido [2,3-b] [1,4]-benzodiazepin-6-ones.
作者信息
Decorte E, Gratton G, Kovac T, Mihalić M, Comisso G, Angeli C, Toso R, Sunjić V
出版信息
Farmaco Sci. 1982 Dec;37(12):787-96.
PMID:7152014
Abstract
The synthesis of 11-acyl-5,11-dihydro-6H-pyrido [2,3-b]-[1,4] benzodiazepin-6-ones (III), (V-IX), is described as well as their spectroscopic characteristics, dipole moments and partition coefficients. The same properties are determined for their N-oxide analogues (X) and (XI), while pharmacological data for some of the above compounds are compared with those of pirenzepin (I), a well known antiulcer drug.
摘要
描述了11-酰基-5,11-二氢-6H-吡啶并[2,3-b]-[1,4]苯并二氮杂卓-6-酮（III）、（V - IX）的合成及其光谱特征、偶极矩和分配系数。还测定了它们的N-氧化物类似物（X）和（XI）的相同性质，同时将上述某些化合物的药理数据与著名的抗溃疡药物哌仑西平（I）的药理数据进行了比较。
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