Rutigliano G, Labout J J
J Int Med Res. 1982;10(6):447-50. doi: 10.1177/030006058201000612.
The bioavailability of orphenadrine hydrochloride after a single intramuscular injection was compared to that after a single oral dose by following serial plasma concentration estimations of the unchanged drug. Eight subjects received 40 mg orphenadrine HCl intramuscularly and 50 mg orally on separate occasions 1 week apart. The bioavailability of orphenadrine from the intramuscular dosage form proved to be equal to or even greater than that from the tablet. The first hour plasma concentrations after intramuscular doses were significantly higher than those after oral doses, supporting the clinical use of the intramuscular route in those indications where rapid effects of the drug are required.
通过连续测定未变化药物的血浆浓度，比较了单次肌内注射盐酸奥芬那君与单次口服给药后的生物利用度。8名受试者在相隔1周的不同时间分别接受了40mg盐酸奥芬那君的肌内注射和50mg的口服给药。结果证明，肌内剂型的奥芬那君生物利用度等于甚至高于片剂。肌内给药后第1小时的血浆浓度显著高于口服给药后的血浆浓度，这支持了在需要药物快速起效的适应症中肌内给药途径的临床应用。
