N-甲基-N-苄基亚硝胺和N,N-二苄基亚硝胺的α-乙酰氧基衍生物在V79细胞中的致突变性：甲基化诱变剂与苄基化诱变剂的比较
Mutagenicity of alpha-acetoxy derivatives of N-methyl-N-benzylnitrosamine and N,N-dibenzylnitrosamine in V79 cells: a comparison between methylating and benzylating mutagens.
作者信息
Huang Kohda K, Anjo T, Mochizuki M, Kawazoe Y, Okada M
出版信息
Gan. 1982 Aug;73(4):517-21.
The mutagenicity and cytotoxicity of N-methyl-N-(alpha-acetoxybenzyl) nitrosamine, N-benzyl-N-(acetoxymethyl) nitrosamine, N-benzyl-N-(alpha-acetoxybenzyl)-nitrosamine and related compounds were examined in V79 Chinese hamster cells. These three alpha-acetoxy nitrosamines were all mutagenic, the first one (a compound ultimately yielding a methylating species) being far more strongly mutagenic than the other two (compounds ultimately giving benzylating species). The alkylating or aralkylating activity of these compounds was determined by assessing their reactivity toward 4-(rho-nitrobenzyl) pyridine. The chemical reactivity-mutagenicity correlation among these alpha-acetoxy nitrosamines and related compounds is discussed in relation to the carcinogenicity of their mother compounds.
在V79中国仓鼠细胞中检测了N-甲基-N-（α-乙酰氧基苄基）亚硝胺、N-苄基-N-（乙酰氧基甲基）亚硝胺、N-苄基-N-（α-乙酰氧基苄基）亚硝胺及相关化合物的致突变性和细胞毒性。这三种α-乙酰氧基亚硝胺均具有致突变性，第一种（一种最终产生甲基化物种的化合物）的致突变性比其他两种（最终产生苄基化物种的化合物）强得多。通过评估这些化合物与4-（对硝基苄基）吡啶的反应活性来确定它们的烷基化或芳烷基化活性。结合这些α-乙酰氧基亚硝胺及其相关化合物母体化合物的致癌性，讨论了它们的化学反应活性与致突变性之间的相关性。
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