美国皮肤利什曼病中的迟发型超敏反应和免疫球蛋白E
Delayed-type hypersensitivity and immunoglobulin E in American cutaneous leishmaniasis.
作者信息
Lynch N R, Yarzábal L, Verde O, Avila J L, Monzon H, Convit J
出版信息
Infect Immun. 1982 Dec;38(3):877-81. doi: 10.1128/iai.38.3.877-881.1982.
Delayed-type hypersensitivity (DTH) and both total and specific immunoglobulin E (IgE) antibody levels were studied during an outbreak of American cutaneous leishmaniasis. Direct correlations were detected between DTH reactivity and either age or the period of evolution of the infection, and a clear association with sex (strongest response in females) was observed. Extremely high, age-dependent, total serum IgE levels were measured in the study group, probably due to concurrent intestinal helminthiasis. A low proportion of the group also had detectable levels of specific anti-Leishmania IgE antibody. Total and specific IgE levels were also sex dependent (lowest in females), and an inverse correlation was found between these levels and DTH responsiveness, possibly reflecting the intervention of regulatory influences of T-lymphocyte activity.
在美国皮肤利什曼病暴发期间，对迟发型超敏反应（DTH）以及总免疫球蛋白E（IgE）和特异性IgE抗体水平进行了研究。检测到DTH反应性与年龄或感染病程之间存在直接相关性，并且观察到与性别有明显关联（女性反应最强）。研究组中测得的总血清IgE水平极高且与年龄相关，这可能是由于同时存在肠道蠕虫感染。该组中也有一小部分人可检测到特异性抗利什曼原虫IgE抗体水平。总IgE和特异性IgE水平也与性别有关（女性最低），并且发现这些水平与DTH反应性呈负相关，这可能反映了T淋巴细胞活性调节作用的干预。
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