Löhle E, Schölmerich J, Vuilleumier J P, Köttgen E
HNO. 1982 Oct;30(10):375-80.
59 patients with chronic alcoholic liver disease and with negative history of ear infection, noise exposure, head injury, use of streptomycin and without hereditary deafness underwent a basic audiologic examination. In all age groups we found a depression of the pure tone threshold on from 2,000 Hz and compared to a control group and to the norm curves (Spoor 1966). Following the Carhart-test and the acoustic facial reflex there were always signs of cochlear lesions. Fifty per cent of the alcoholics in the Carhart tone decay test showed a depression of the threshold between 10 and 30 dB. The concentration of vitamin A, RBP, beta-Carotin and zinc in the blood measured at the same time were diminished. Considering recent electron microscopic findings on the pattern of the inner ear of young rats following vitamin A deficit we suppose that the vitamin A deficit in the alcoholics leads to poor hearing.
59例慢性酒精性肝病患者,无耳部感染、噪声暴露、头部损伤、使用链霉素病史且无遗传性耳聋,接受了基本的听力学检查。在所有年龄组中,我们发现与对照组和正常曲线(Spoor,1966)相比,从2000赫兹起纯音阈值降低。经过卡哈特测试和听觉面反射检查,总是存在耳蜗病变的迹象。在卡哈特音调衰减测试中,50%的酗酒者阈值降低了10至30分贝。同时测量的血液中维生素A、视黄醇结合蛋白、β-胡萝卜素和锌的浓度降低。考虑到最近关于维生素A缺乏的幼鼠内耳模式的电子显微镜研究结果,我们推测酗酒者体内维生素A缺乏导致听力下降。