Slanina J, Wannenmacher M, Kuphal K, Knüfermann H, Beck C, Schilli W
Int J Radiat Oncol Biol Phys. 1982 Oct;8(10):1683-9. doi: 10.1016/0360-3016(82)90287-5.
Thirty-two patients with histologically proven carcinoma of the oral tongue, Stage T1-3, were analyzed retrospectively. They were treated from January 1964 through July 1980 in Freiburg by interstitial implantation with Au-198-seeds for the primary tumor management. Out of 25 patients with complete follow-up, one patient developed a local recurrence. In three patients, regional lymph node metastases occurred, once after prior adjuvant radiotherapy to the regional lymph nodes area, and in two patients after exclusive interstitial radiotherapy to the tumor of the tongue. The overall five-year survival rate was 52% for all stages (overall group), 75% for Stage T1 and 44% for Stages T2-3. The corrected five-year survival rate was 75% for all stages, 86% for Stage T1 and 71% for Stages T2-3. The method of 198Au-seed implantation as it is practiced in Freiburg is discussed, as well as the radiation exposure of the personnel.
对32例经组织学证实为口腔舌癌、T1 - 3期的患者进行了回顾性分析。1964年1月至1980年7月期间，他们在弗莱堡接受了金-198籽粒间质植入治疗原发性肿瘤。在25例有完整随访资料的患者中，1例出现局部复发。3例发生区域淋巴结转移，1例在区域淋巴结区先行辅助放疗后出现，2例在仅对舌部肿瘤进行间质放疗后出现。所有分期（总体组）的总体五年生存率为52%，T1期为75%，T2 - 3期为44%。校正后的五年生存率，所有分期为75%，T1期为86%，T2 - 3期为71%。讨论了弗莱堡所采用的198Au籽粒植入方法以及工作人员的辐射暴露情况。
