Tsujino K, Oshitani T, Kushima T, Mieda C, Hirota S, Ogawa K, Maruta T, Ikeda Y, Ueda E, Suematsu T
Department of Radiology, Hyogo Medical Center for Adults.
Nihon Igaku Hoshasen Gakkai Zasshi. 1991 Jun 25;51(6):671-7.
One hundred patients with T1-2NO squamous cell carcinoma of the oral tongue were treated with interstitial brachytherapy at the Hyogo Medical Center for Adults between 1962 and 1983. These patients were followed for more than two years. The cumulative five-year survival rate was 89% in T1N0 and 66% in T2N0. The relapse-free survival rate was 88% in T1N0 and 51% in T2N0. The two-year local control rate in the primary site was 100% in T1N0 and 73% in T2N0. Cervical node metastases developed in 41% (T1N0: 33%, T2N0: 43%) of the patients. The five-year survival rate of the patients with subsequent cervical node metastases was 42%, while that of patients without subsequent cervical node metastases was 92% (p less than 0.001). Twenty-seven patients also received prophylactic neck irradiation (average dose: 33.8 Gy). In patients treated with prophylactic neck irradiation, the rate of subsequent cervical node metastases was 37% and the cumulative five-year survival rate was 62%. In the patients without prophylactic neck irradiation, these figures were 41% and 73%, respectively. There was no statistically significant difference between the two groups. Between 1984 and 1986, 28 patients with T1-2 N0 squamous cell carcinoma of the oral tongue were treated with interstitial brachytherapy. These patients were prospectively examined for the ability of chemotherapy to prevent the development of cervical node metastasis. In 13 patients treated with chemotherapy (CDDP 80 mg/m2 + PEP 6 mg/m2 x 5 days), the two-year local control rate was 90%, the incidence of cervical node metastases was 38% and the incidence of distant metastases was 15%.(ABSTRACT TRUNCATED AT 250 WORDS)
1962年至1983年间，100例口腔舌部T1-2NO期鳞状细胞癌患者在兵库成人医疗中心接受了组织间近距离放射治疗。这些患者随访时间超过两年。T1N0期患者的累积五年生存率为89%，T2N0期为66%。T1N0期患者的无复发生存率为88%，T2N0期为51%。T1N0期患者原发部位的两年局部控制率为100%，T2N0期为73%。41%的患者发生了颈部淋巴结转移（T1N0期：33%，T2N0期：43%）。发生颈部淋巴结转移的患者五年生存率为42%，未发生颈部淋巴结转移的患者五年生存率为92%（p<0.001）。27例患者还接受了预防性颈部照射（平均剂量：33.8 Gy）。接受预防性颈部照射的患者中，后续颈部淋巴结转移率为37%，累积五年生存率为62%。未接受预防性颈部照射的患者，这两个数字分别为41%和73%。两组之间无统计学显著差异。1984年至1986年间，28例口腔舌部T1-2 N0期鳞状细胞癌患者接受了组织间近距离放射治疗。这些患者接受了关于化疗预防颈部淋巴结转移能力的前瞻性检查。13例接受化疗（顺铂80 mg/m2 + 平阳霉素6 mg/m2×5天）的患者，两年局部控制率为90%，颈部淋巴结转移发生率为38%，远处转移发生率为15%。（摘要截短于250字）
