van der Werf-Messing B H, Friedell G H, Menon R S, Hop W C, Wassif S B
Int J Radiat Oncol Biol Phys. 1982 Nov;8(11):1849-55. doi: 10.1016/0360-3016(82)90441-2.
One hundred eighty-three patients with bladder cancer category T3NxMo (the diameter of the primary exceeding 5 cm), were treated by preoperative 40 Gy and simple cystectomy. Using only pretreatment information, the group with the best prognosis was characterized by a T3A-growth with a normal intravenous pyelography, with about a 75% cure rate. Before cystectomy, after irradiation the combination of a clinically assessed radiation-downstaged growth (T40GY less than 3) with normal urography, predicted the best chance of cure at about 80%. After cystectomy was performed, the best prognostic group could be most correctly identified: those patients with both microscopic downstaging of the primary ("P" less than 3) and no vascular invasion in the cystectomy specimen (CV-) combined with normal urography had an 81% chance of cure. This most favorable group constitutes 45% of all patients.
183例T3NxM0期膀胱癌患者（原发灶直径超过5cm）接受了术前40Gy放疗及单纯膀胱切除术。仅根据治疗前信息，预后最佳的组具有T3A期生长且静脉肾盂造影正常的特点，治愈率约为75%。膀胱切除术前，放疗后临床评估为放疗降期生长（T40GY<3）且尿路造影正常的患者，治愈几率最佳，约为80%。膀胱切除术后，可最准确地识别出预后最佳的组：那些原发灶镜下降期（“P”<3）且膀胱切除标本无血管侵犯（CV-）并伴有尿路造影正常的患者，治愈几率为81%。这一最有利的组占所有患者的45%。
