Michael R P, Zumpe D, Bonsall R W
J Comp Physiol Psychol. 1982 Dec;96(6):875-85.
Daily subcutaneous injections of estradiol, progesterone, and testosterone were given to ovariectomized rhesus monkeys in amounts that imitated accurately the changing plasma levels of hormones in intact females with natural menstrual cycles. Because these cycles in ovariectomized, treated females were terminated by normal vaginal bleeding every 28 days and showed a mid-cycle gonadotropin surge, we termed them "artificial menstrual cycles." In dyadic mating tests, changes in the females' access times (lever pressing) for males, and in the males' ejaculatory performance, were closely similar during natural and artificial cycles, and there were well-marked behavioral rhythms. These rhythms were lost during 28-day control periods when ovariectomized females received injections of vehicle alone. Differences in ejaculatory performance during natural and artificial cycles could be accounted for by an order effect. It is concluded that the artificial cycle provides a valid and useful paradigm for a more detailed study of the neuroendocrine regulation of primate reproductive behavior.
对切除卵巢的恒河猴每日进行皮下注射雌二醇、孕酮和睾酮，注射剂量精确模拟有自然月经周期的完整雌性动物体内激素水平的变化。由于这些接受治疗的切除卵巢的雌性动物的周期每28天会因正常阴道出血而结束，且在周期中期会出现促性腺激素高峰，我们将其称为“人工月经周期”。在二元交配试验中，雌性接近雄性的时间（按压杠杆）变化以及雄性的射精表现，在自然周期和人工周期中非常相似，且存在明显的行为节律。当切除卵巢的雌性动物在28天的对照期内仅接受赋形剂注射时，这些节律消失。自然周期和人工周期中射精表现的差异可由顺序效应来解释。结论是，人工周期为更详细地研究灵长类动物生殖行为的神经内分泌调节提供了一个有效且有用的范例。
