Fabre-Nys C
C R Seances Acad Sci D. 1979 Dec 17;289(16):1319-22.
Ovariectomized adult Ewes daily treated with I/M injections of testosterone propionate (10 mg/day) or oestradiol benzoate (200 microgram/day) show male-like sexual behaviour and simultaneously a permanent female receptivity. Additional daily treatment with 100 mg of progresterone results in a rapid decrease in male sexual responses both when Ewes are treated with testosterone and with oestradiol. No effect is observed on the female receptivity. Cyproterone acetate (100 mg/day) given to Ewes in addition to daily injection of testosterone propionate (10 mg/day) has effects similar to those of progesterone. These results show that progesterone has antiandrogen and antioestrogen properties and that this hormone administered at high doses is able to inhibit male activity.
成年去势母羊每天肌肉注射丙酸睾酮（10毫克/天）或苯甲酸雌二醇（200微克/天）后会表现出类似雄性的性行为，同时保持永久性的雌性接受性。每天额外给予100毫克孕酮进行治疗，无论母羊接受睾酮还是雌二醇治疗，都会导致雄性性反应迅速下降。对雌性接受性没有影响。除了每天注射丙酸睾酮（10毫克/天）外，给母羊注射醋酸环丙孕酮（100毫克/天）会产生与孕酮类似的效果。这些结果表明，孕酮具有抗雄激素和抗雌激素特性，高剂量施用这种激素能够抑制雄性活动。
